Genetic and pathophysiological substantiation of polyphenolic grape processing products’ application in the treatment of metabolic syndrome in the population of the Republic of Crimea

Adipose tissue in abdominal obesity produces various cytokines, the most important of which is adiponectin (AN). Polymorphism AN receptor genes associated with risk metabolic syndrome (MS) and type 2 diabetes mellitus (DM2) development. The aim study was to investigate association receptors’ polymorphism development MS DM2 Republic Crimea as well possibility named pathology correction polyphenolic functional foods. included 100 patients confirmed diagnosis MS. Genomic DNA isolated from whole blood patients. Gene amplification performed by PCR real-time. common genotype ADIPOQ gene (rs1501299) among GT G276T. frequent genotypes ADIPOR1 were AC (rs2275737) – 53.3% CT (rs2275738) - 50.0%. combinations between /CT 28.6%, (rs2275737)/CT GG 19.7%. Thus, Crimea, associations receptors this have been established. It known that polyphenols red grape varieties are epigenetic modifiers. Therefore, these products can be individual nutrition programs population groups genetically predisposed DM2.